【摘要】 目的 探讨不同年龄组的儿童特发性血小板减少性紫癜与病毒感染及血小板相关抗体的关系。方法 应用PCR技术检测117例患儿VB19、CMV和EBV三种病毒的感染情况，并用ELISA技术测定患儿外周血中pAIgG和pAIgM。结果 117例患儿VB19，CMV，EBV的感染率分别为35%、3.4%和3.4%。VB19感染率在≤3岁组为60%，而在>3岁组其感染率仅为25%，经χ 2 检验，P<0.01，差异有显著性。血小板相关抗体pAIgG，pAIgM在≥2岁，<6岁组的检测阳性率分别为29%和55%;而在≥6岁，≤14岁组其检测阳性率分别为88%和53%;经χ 2 检验pAIgG在两组间差异有显著性。结论 ≤3岁组儿童ITP发生与VB19感染关系密切;≥2岁，<6岁组ITP患儿血小板相关抗体产生主要为pAIgM。而pAIgG和pAIgM在≥6岁，≤14岁组ITP发生中均起了作用。

    关键词 病毒 抗体 紫癜 血小板减少性 儿童

    The study of relationship among idiopathic thrombocytopenic purpura，virus

    infection and platelet-associated autoantibody in different age children

    Zhu Jie，Chai Yihuan，Ji Zhenghua，et al.

    Department of Pediatrics，Children Hospital，Suzhou University，Suzhou215003.

    【Abstract】 Objective The study of relationship among idiopathic thrombocytopenic purpura，virus infection and platelet-associated autoantibody in different age children.Methods One hundred and seventeen peripheral blood samples were collcced from children who were diagnosed as ITP.The PCR was performed to detect the DNA of CMV ......