【摘要】 目的 观察和比较甲钴胺与泼尼松治疗周围性面瘫的成本和效果。 方法 按照临床诊断标准收集周围性面瘫病例130例，按随机化方法，分为甲钴胺组和泼尼松组，应用成本效果分析法进行评价。 结果 (1)临床疗效:甲钴胺组面部评分88.25±9.96优于泼尼松组62.97±10.09(P<0.01)。(2)治疗总费用:甲钴胺组平均为3111.97±1154.58元;泼尼松组平均为3348.67±853.22元(P>0.05)。(3)成本效果比:甲钴胺组成本效果比为3111.97/(88.25-35.48)=58.97，表明平均每提高一个面部评分值，需花费58.97元;泼尼松组3348.67/(62.97-33.79)=114.76，表明平均每提高一个面部评分值需花费114.76元。 结论 甲钴胺组有更好的成本效果比，应作为临床治疗的首选药物。

    关键词 甲钴胺 泼尼松 药物经济学 成本效果分析法

    Economic evaluation of methylcobalamin and prednisone in the

    treatment of peripheral facial paralysis

    Yuan Yi，Chen ShengXin，Kuai Liping

    Department of Pharmacy Administration，College of Pharmacy，Second Military Medical University，Shanghai200433.

    【Abstract】 Objective To observe and evaluate the cost and effectiveness of methylcobalamin and prednisone in the treatment of peripheral facial paralysis.Methods According to the clinical diagnosis standard，130cases of Peripheral facial paralysis were divided to two groups by randomization.The cost-effectiveness analysis were used.Results (1)clinic effectiveness:methylcobalamin group got88.25±9.96clinic grade ......