利用 SELDI-TOF-MS 技术研究巨细胞病毒感染致婴儿肝炎综合征的血清蛋白标志物
http://www.100md.com
张 妍, 刘华林, 王 斌, 钱冬萌, 闫志勇,
SELDI-TOF-MS;蛋白质组学;婴儿肝炎综合征;先天性巨细胞病毒感染,利用SELDI-TOF-MS技术研究巨细胞病毒感染致婴儿肝炎综合征的血清蛋白标志物,张妍,王斌,钱冬萌,闫志勇
 |
| 第1页 |
参见附件(489KB，5页)。
张妍, 王斌, 钱冬萌, 闫志勇, 丁守怡, 宋旭霞, 宋广辉, 青岛大学医学院医药生物技术重点实验室 山东省青岛市 266021
刘华林, 青岛市妇女儿童医疗保健中心内二科 山东省青岛市 266011
张妍, 女, 1980-03-11生, 山东省莱州市人, 汉族, 2003年青岛大学医学院硕士生.
国家自然科学基金资助项目 No.C30471527
通讯作者: 王斌, 266021, 山东省青岛市登州路38号, 青岛大学医学院医药生物技术重点实验室. wangbin31@yahoo.com
收稿日期: 2005-09-21 接受日期: 2005-09-30
Identification of serum biomarkers in human cytomegalovirus infected hepatitis infants by SELDI-TOF-MS
Yan Zhang, Hua-Lin Liu, Bin Wang, Dong-Meng Qian, Zhi-Yong Yan, Shou-Yi Ding, Xu-Xia Song, Guang-Hui Song
Yan Zhang, Bin Wang, Dong-Meng Qian, Zhi-Yong Yan, Shou-Yi Ding, Xu-Xia Song, Guang-Hui Song, Key Laboratory of Medicine and Biotechnology, Medical College of Qingdao University, Qingdao 266021, Shandong Province, China
Hua-Lin Liu, the Second Department of Internal Medicine, Medicare Center for Women and Children, Qingdao 266011, Shandong Province, China
Supported by National Natural Science Foundation of China, No. C30471527
Correspondence to: Dr. Bin Wang, Key Laboratory of Medicine and Biotechnology, Medical College of Qingdao University, 8 Dengzhou Road, Qingdao 266021, Shandong Province, China. wangbin31@yahoo.com
Received: 2005-09-21 Accepted: 2005-09-30
Abstract
AIM: To identify the serum protein biomarkers in infants with hepatitis syndrome resulted from congenital human cytomegalovirus (hCMV) infected using Surface enhanced laser desorption/ionization-time of flight mass spectrometry (SELDI-TOF-MS).
METHODS: Serum samples were collected from 20 hCMV infected hepatitis infants and 25 controls. Of the 25 infants, 5 were infected with hCMV but without hepatitis, 10 with hepatitis but no hCMV infection, and 10 were healthy infants. The proteomic expression in the serum was detected by WCX2 chips and SELDI-TOF-MS.
RESULTS: Fifteen protein peaks were distinctly di-fferent among the four groups in the mass range of Mr 2 000-20 000 ......
您现在查看是摘要介绍页，详见PDF附件(489KB，5页)。