愈肝胶囊体外抗乙型肝炎病毒的作用
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高 萍, 程留芳, 谢朝良
愈肝胶囊;2.2.15细胞;乙肝病毒;抗HBV活性高萍,程留芳,谢朝良.愈肝胶囊体外抗乙型肝炎病毒的作用.世界华人消化杂志2005;13(22)2693-26960引言,愈肝胶囊体外抗乙型肝炎病毒的作
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高萍, 程留芳,北京市解放军总医院消化科 北京市 100853
谢朝良, 四川省泸州医学院附属第二医院四川省泸州市 646000
通讯作者:高萍, 100853, 北京市复兴路28号,北京市解放军总医院消化科. greenpla@163.com
电话: 010-89861915
收稿日期: 2005-08-05 接受日期: 2005-08-26
Inhibitory effect of Yugancapsule on hepatitis B virus in vitro
Ping Gao, Liu-Fang Cheng, Chao-Liang Xie
Ping Gao, Liu-Fang Cheng, Departmentof Gastroenterology, General Hospital of Chinese PLA, Beijing 100853,China
Chao-Liang Xie, the Second Affiliated Hospital of Luzhou MedicalCollege, Luzhou 646000, Sichuan Province, China
Correspondence to: Ping Gao, Department of Gastroenterology,General Hospital of Chinese PLA, 28 Fuxing Road, Beijing 100853, China. greenpla@163.com
Received: 2005-08-05 Accepted: 2005-08-26
Abstract
AIM:To investigate the anti-hepatitis B virus effect of Yugancapsule in vitro.
METHODS:The experimental rabbits (n = 6) were randomlydivided into 3 groups (2 for each), and then were treated with the normalserum, Yiganning granule and Yugan capsule, respectively.The blood samples were collected from the hearts and diluted into variousconcentrations. The effects of the serums on the 2.2.15 cell line wereobserved. Enzyme linked immunosorbent assay was used to detect the thecontents of HBsAg and HBeAg, and polymerase chain reaction andhybridization were used to determine the contents of HBV DNA.
RESULTS:Five days after treatment, Yugan capsule of 1∶1group had significant anti-HBV effect in comparison with Yiganninggranule (HBsAg: 53.93±1.34 vs 41.03±0.85, P <0.05; HBeAg:55.25±1.42 vs 36.26±0.97, P <0.01; HBV DNA: 56.81±2.37 vs43.71±0.98, P <0.01), while Yugan capsule of 1∶2,1∶4, and 1∶8group was not markedly different, and that of 1∶16group had less anti-HBV effect. Ten days after treatment, Yugan capsule ofdifferent concentrations inhibited the proliferation of HBV significantlyin comparison with cell control and normal serum group, while incomparison with Yiganning granule, Yugan capsule of 1∶1group notably inhibited the replication of HBV DNA (67 ......
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