瘦素和 TGF-α 在幽门螺杆菌感染慢性胃炎和胃溃疡患者胃黏膜内的表达及意义
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李点玲, 张桂英
瘦素;转化生长因子-α;幽门螺杆菌;慢性胃炎;胃溃疡,瘦素和TGF-α在幽门螺杆菌感染慢性胃炎和胃溃疡患者胃黏膜内的表达及意义,李点玲,张桂英,通讯作者:,Expressionandsignifi
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李点玲, 广州市芳村区人民医院 广东省广州市 510370
张桂英, 中南大学湘雅医院消化科 湖南省长沙市 410008
通讯作者: 张桂英, 410008, 湖南省长沙市湘雅路88号, 中南大学湘雅医院. guiyingzhang@hotmail.com
电话: 0731-4327106
收稿日期: 2005-07-28 接受日期: 2005-08-31
Expression and significance of leptin and transforming growth factor-α in gastric mucosa of Helicobacter pylori infected patients with chronic gastritis and gastric ulcer
Dian-Ling Li, Gui-Ying Zhang
Dian-Ling Li, the People’s Hospital of Fangcun District, Guangzhou 510370, Guangdong Province, China
Gui-Ying Zhang, Xiangya Hospital of Central South University, Changsha 410008, Hunan Province, China
Correspondence to: Gui-Ying Zhang, Xiangya Hospital of Central South University, 88 Xiangya Road, Changsha 410008, Hunan Province, China. guiyingzhang@hotmail.com
Received: 2005-07-28 Accepted: 2005-08-31
Abstract
AIM: To investigate the expression of leptin and trans-forming growth factor-α (TGF-α) in the H pylori infected gastric mucosa, and to explore the correlation between leptin and TGF-α.
METHODS: Immunocytochemistry was used to detect the expression of leptin and TGF-α in the mucosal biopsies from the corpus ventriculi and the gastric antrum of patients with H pylori + and H pylori - chronic gastritis and gastric ulcer.
RESULTS: Leptin was weakly positive in the corpus ventriculi mucosa of normal person. The expression of leptin and TGF-α were significantly increased in the corpus ventriculi mucosa of H pylori + infected patients with gastritis and gastric ulcer as compared with that in the H pylori - patients (leptin: 73.33% vs 23.08%, P <0.05; 70.59% vs 25.00%, P <0.05; TGF-α: 73.33% vs 15.38%, P <0.05; 76.47% vs 25.00%, P <0.05). The expression of leptin had no significant difference in the gastric antral mucosa between the four groups (P >0.05). The expression of TGF-α was markedly higher in the gastric antral mucosa of patients with H pylori + chronic gastritis than that in patients with H pylori - gastritis (53 ......
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