【摘要】 目的 比较喜普妙与赛乐特对强迫症的临床疗效及不良反应。方法 将40例符合CCMD-3强迫症的患者随机分为两组，分别应用喜普妙与赛乐特治疗，疗程12周，采用Yale-Brown强迫症量表(Y-BOCS)，临床疗效总评量表的病情严重程度(CGI-SI)和不良反应量表(TESS)评定疗效和不良反应。结果 喜普妙组与赛乐特组临床疗效相似(P>0.05)，且起效时间相近，两组治疗前后Y-BOCS总分和CGI-SI评分比较差异有显著性(P<0.05)，喜普妙组与赛乐特组副反应发生率差异无显著性(P>0.05)。结论 喜普妙与赛乐特对强迫症均有较好的治疗效果，起效快，不良反应少，耐受性好。

    【关键词】 强迫症；喜普妙；赛乐特

    A controlled study of citalopram and seroxat in the treatment of obsessive compulsive disorder

    LIU Guo-xiong,CAI Ying-lian.

    Guangzhou Psychiatric Hospital, Guangzhou 510370, China

    【Abstract】 Objective The purpose of this study was to investigate the clinical efficacy and the adverse effects of citalopram and seroxat in the treatment of obsessive compulsive disorder (OCD).Methods 40 patients met the CCMD-3 criteria for OCD were randomly divided into two groups. The two groups were treated with citalopram and seroxat both for 12 weeks respectively. The efficacy was assessed with Y-BOCS and CGI-SI. The adverse effects were assessed with Treatment Emergent Symptoms Scale (TESS). Results The results were no significant differences between the two groups. The adverse effects of citalopram was similar to seroxat.Conclusion Citalopram is an effective antidepressant with few adverse effects and takes into effect rapidly. ......