多烯紫杉醇体内对肝癌放化疗及其对p21和bcl-2表达影响
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耿长新, 曾昭冲, 周长宏, 王吉耀, 亓玉琴
多烯紫杉醇;裸鼠;肝癌;放射增敏;p21;bcl-2,耿长新,周长宏,亓玉琴,曾昭冲,王吉耀,通讯作者:,电话:,收稿日期:,接受日期
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耿长新, 周长宏, 亓玉琴, 青岛大学医学院附属市立医院东院区消化科 山东省青岛市 266071
曾昭冲, 复旦大学附属中山医院放疗科 上海市 200032
王吉耀, 复旦大学附属中山医院消化科 上海市 200032
耿长新, 男, 1964-08-02 生, 山东省滨州市人, 汉族, 2003年复旦大学博士研究生, 副主任医师, 主要从事消化道疾病和肝癌治疗研究.
通讯作者: 耿长新, 266071, 山东省青岛市东海中路5号, 青岛大学医学院附属市立医院东院区消化科. changxin_geng@hotmail.com
电话: 0532-82639928
收稿日期: 2005-07-28 接受日期: 2005-11-12
Antitumor and radiosensitizing effect of docetaxel on human hepatocellular carcinoma and its mechanisim in vivo
Chang-Xin Geng, Zhao-Chong Zeng,Chang-Hong Zhou, Ji-Yao Wang, Yu-Qin Qi
Chang-Xin Geng, Chang-Hong Zhou, Yu-Qin Qi, Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, Shandong Province, China
Zhao-Chong Zeng, Department of Radiation Oncology, the Affiliated Zhongshan Hospital of Fudan University, Shanghai 200032, China
Ji-Yao Wang, Department of Gastroenterology, the Affiliated Zhongshan Hospital of Fudan University, Shanghai 200032, China
Correspondence to: Dr. Chang-Xin Geng, Department of Gastro-enterology, Qingdao Municipal Hospital, Qingdao 266071, Shandong Province, China. changxin_geng@hotmail.com
Received: 2005-07-28 Accepted: 2005-11-12
Abstract
AIM: To investigate the anti-human hepatocellular carcinoma (HCC) activity of docetaxel and determine the potential radiosensitizing effect of docetaxel in vivo, and to further explore the mechanism of docetaxel-induced cell growth inhibition, apoptosis and radiosensitization at gene level.
METHODS: Nude mice bearing HCC with a diameter of about 0.8 cm in the leg received 33 mg/kg docetaxel intraperitoneally, 10 Gy (5 Gy once) tumor irradiation, or both (radiation given 24 and 48 h after docetaxel treatment). The regression and regrowth of the tumors were followed until the tumor diameter reached 1.4 cm approximately. Absolute growth delay (AGD), which was defined as the time in days for tumors treated with docetaxel to grow from 0 ......
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