β- 连环素在肝癌中的表达及其与 cyclin D1 表达的关系
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曾建平, 易继林, 李兴睿, 杨志芳, 王从俊
肝细胞癌;β-catenin;CyclinD1;免疫组织化学,β-连环素在肝癌中的表达及其与cyclinD1表达的关系,曾建平,易继林,李兴睿,杨志芳,王从俊,Expressionofβ-caten
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曾建平, 易继林, 李兴睿, 杨志芳, 王从俊, 华中科技大学同济医学院附属同济医院普通外科 湖北省武汉市 430030
通讯作者: 曾建平, 430030, 湖北省武汉市, 华中科技大学同济医学院附属同济医院普通外科. zjpdoc@163.com
电话: 027-83663418
收稿日期: 2005-09-10 接受日期: 2005-09-30
Expression of β-catenin in hepatocellular carcinoma and its relation with cyclin D1 expression
Jian-Ping Zeng, Ji-Lin Yi, Xing-Rui Li, Zhi-Fang Yang, Cong-Jun Wang
Jian-Ping Zeng, Ji-Lin Yi, Xing-Rui Li, Zhi-Fang Yang, Cong-Jun Wang,Department of General Surgery, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Correspondence to: Jian-Ping Zeng, Department of General Surgery, the Affiliated Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. zjpdoc@163.com
Received: 2005-09-10 Accepted: 2005-09-30
Abstract
AIM: To investigate the expression of β-catenin in hepatocellular carcinoma (HCC) and its effect on the expression of cyclin D1.
METHODS: The immunohistochemical SP staining technique was performed to detect the expression of β-catenin and cyclin D1 in 51 liver tissue samples, including 5 cases of normal liver, 8 cases of liver cirrhosis, and 38 cases of HCC.
RESULTS: In normal and cirrhotic liver, the weak expression of β-catenin was observed in the cell membrane. The aberrant expression of β-catenin, mainly located at the cell cytoplasm, was detected in 21 (55.2%) of the 38 HCC tissues and significantly higher in the tissues with poor differentiation and metastasis than that in the ones with well differentiation and non-metastasis. There was a significant correlation between the aberrant expression of β-catenin and the over expression of cyclin D1 (P = 0.017). Of the 38 HCC tissue samples, 13 were found aberrant expression of β-catenin combined with positive expression of cyclin D1 (34%), and 15 were found normal expression of β-catenin combined with negative cyclin D1 expression (39%) ......
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