关键词: 肝硬化/放射性核素显像;大鼠;胃排空;胃肠通过实验

    摘 要:目的 研究肝硬化大鼠胃肠运动功能的变化. 方法 制备CCl4 中毒性肝硬变大鼠模型，99 Tcm -DTPA标记钡剂，分别对8只正常对照鼠和8只肝硬变模型鼠进行核素胃排空功能检查和全胃肠钡剂通过时间(TGIT)观测. 结果 肝硬化模型组鼠胃半排空时间(GET1/2)为124.0min，2h残留率为54.9%，正常对照组鼠GET1/2为33.7min，2h残留率为13.7%，肝硬化模型组较正常对照组胃半排空时间明显减慢(P<0.01)，有显著性差异.肝硬化鼠TGIT为12.4h，正常组鼠为9.5h，两者相差显著(P<0.01). 结论 肝硬化鼠胃排空较正常鼠明显减慢，胃肠传递时间明显延长.

    Changes of gastrointestinal motility in rats with CCl4 induced cirrhosis

    ZHANG Zong-You，WANG Xin，XUHai-Feng，MU Ji-Zhen，MA Yu-Bo，MIAO Ji-Yan，GUO Xue-Gang，FAN Dai-Ming

    1 Institute of Gastroenterology of Chinese PLA，Xi-jing Hospital; 2 Department of Nuclear Medicine，Tangdu Hospital，Fourth Military Medical Univer-sity，Xi'an710033，China

    Keywords:liver cirrhosis;rats;gastric emptying;gastroin-testinal transit

    Abstract:AIM To investigate the changes of gastroin-testinal motility in rats with carbon tetrachloride-induced cir┐rhosis.METHODS Half gastric emptying time(GET)and trans-gastrointestinal time in cirrhotic rats were observed by using99 Tcm -DTPA-labled barium sulfate as test meal.RE┐SULTS Half gastric emptying time was significantly in-creased from33.7min in controls to124.0min in cirrhotic rats ......