【摘要】 目的 探讨卵巢癌患者血清TPS、CA125水平的临床应用价值。方法 分别检测15例卵巢良性肿瘤患者(良性对照组)和39例卵巢癌患者(卵巢癌组)初诊、治疗后以及15例卵巢癌复发患者血清TPS、CA125水平，统计结果进行比较。结果 卵巢癌组血清TPS、CA125水平显著高于良性对照组(P<0.01)；TPS对卵巢癌诊断的灵敏度和特异度为71.8%和86.7%，CA125为84.6%和86.7%，两者差异无显著性(P>0.05)；治疗后患者血清TPS、CA125水平低于治疗前(P<0.01、P<0.05)，而复发时TPS水平又显著高于治疗后(P<0.05)。结论 血清TPS检测有助于卵巢癌诊断、疗效观察及预后判断，联合检测CA125可提高其临床应用价值。

    【关键词】 组织多肽特异性抗原；卵巢癌；卵巢特异性抗原

    Serum TPS，CA125 level in ovarian cancer patients and its clinical significance

    TANG Xiao-ming,LIAN Jian-xue, ZHANG Yan-li.

    General Laboratory of Medical College,Henan University of Science and Technology,Luoyang 471003,China

    【Abstract】 Objective To explore the clinical applying value of serum tissue polypeptide specific antigen(TPS)、CA125 level in patients with ovarian carcinoma.Methods We detected respectively the serum TPS、CA125 level of 15 patients with ovarian benign tumor and 39 patients with ovarian carcinoma after the first visit and treatment,as well as of 15 ovarian cancer palindromic patients.And their results were classified and compared.Results The serum TPS、CA125 level of the ovarian cancer group was significantly higher than the ovarian benign tumor group(P<0.01).TPS’s sensibility and specificity to the diagnosis of ovarian cancer were 71.8% and 86.7% ......