Keywords:bone morphogenetic protein;bone transplanta-tion;transplantation，heterologous;periosteum CLC number:R686.34 Document code:A

    Abstract:AIM To study the efficacy of rhBMP2/BCB used alone and combined use of rhBMP2/BCB and vascularized pe-riosteal graft in repairing segmental bony defects.METHODS A new grafting material(rhBMP2/BCB)was made by combining recombinant human BMP2(rhBMP2)and an anti-gen-free bovine cancellous bone(BCB)as a carrier.rhBMP2/BCB was used alone，in conjunction with vascular-ized periosteal graft to repair a1.5cm defect in the radius of the rabbit.The defect-repairing capability for each of the treatment modalities was assessed radiographically，biome-chanically，by densitometry and histological studies.RESULTS ①rhBMP2/BCB used alone was capable of heal-ing the defect in large part by16wk，with a similar repair process and mechanism to that seen with RBX;②use of rhBMP2/BCB in conjunction with vascularized periosteal graft exhibited stronger defect-repairing power，basically healing the defect by8wk.The repair process consisted of intramembranous and endochondral ossification that resem-bled the physiological repair during the fracture healing.CONCLUSION Both methods are effective in repairing seg-mental bony defects ......