视黄醇脂对慢性酒精性肝病患者肝脏纤维化的抑制作用
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刘中宏, 郑长青, 李春明
视黄醇脂;胶原血清Ⅲ型前胶原肽;血清透明质酸刘中宏,郑长青,李春明.视黄醇脂对慢性酒精性肝病患者肝脏纤维化的抑制作用. 世界华人消化杂志2006;14(2)234-237,视黄醇脂对慢性酒
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刘中宏, 郑长青,中国医科大学附属二院消化内科 辽宁省沈阳市 110004
李春明,哈尔滨市第一医院消化内科黑龙省哈尔滨市 150010
通讯作者:刘中宏, 110004, 辽宁省沈阳市和平区三好街36号,中国医科大学附属二院消化内科.liuzhonghong@medmail.com.cn
收稿日期: 2005-11-23 接受日期: 2005-12-08
Effect of vitamin A on hepatic cirrhosis in patientswith chronic alcoholic liver disease
Zhong-Hong Liu, Chang-Qing Zheng, Chun-Ming Li
Zhong-Hong, Chang-Qing Zheng,Department of Gastroenterology, the Second Affiliated Hospital of ChinaMedical University, Shenyang 110004, Liaoning Province, China
Chun-Ming Li, Department of Gastroenterology, the First Hospital ofHarbin, Harbin 150010, Heilongjiang Province, China
Correspondence to: Zhong-Hong Liu, Department of Gastroenterology,the Second Affiliated Hospital of China Medical University, 36 SanhaoStreet, Heping District, Shenyang 110004, Liaoning Province,China. liuzhonghong@medmail.com.cn
Received: 2005-11-23 Accepted: 2005-12-08
Abstract
AIM: To prove the inhibitoryeffect of vitamin A (Vit A) on the formation of liver fibrosis in patientswith chronic alcoholic liver disease (ALD).
METHODS: Fiftypatients were assigned into Vit A and Huganpian treatment group(controls). After corresponding treatment for 6, 12 and 18 mo, the levelsof serum procollagen Ⅲpeptide (PⅢP)and hyaluronic acid (HA) were detected by enzyme linked immunosorbentassay (ELISA).
RESULTS: After18 mo of the Vit A treatment, the levels of PⅢP(16.9 ± 6.8 mg/Lvs 28.2 ± 9.7 mg/L)and HA (132.3 ± 71 mg/Lvs 210.0 ± 87 mg/L)were significantly decreased as compared with those before the treatment(both P < 0.01), and there was also significant differencebetween the treatment group and the control group (PⅢP:16.9 ± 6.8 mg/Lvs 23.6 ± 9.6 mg/L,P < 0.01; HA: 132.3 ± 71 mg/Lvs 192.0 ± 97 mg/L,P < 0.05).
CONCLUSION: Vit A cansuppress hepatic fibrogenesis of ALD patients, and the mechanism may berelated to its inhibition on the release of collagen ......
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