益肝康等活血化瘀中药抑制 IL-1b刺激的 HSC 增殖及TIMP-1 的表达

http://www.100md.com 赵 霞, 姚希贤, 张亚平, 郑文明

鍏抽敭璇嶏細益肝康;白细胞介素-1b;肝星状细胞;基质金属蛋白酶-1赵霞,姚希贤,张亚平,郑文明.益肝康等活血化瘀中药抑制IL-1b刺激的HSC增殖及TIMP-1的表达.世界华人消化杂志2006;14(2)173

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     赵霞, 姚希贤, 张亚平, 河北医科大学第二医院消化内科河北省石家庄市 050000

    郑文明, 唐山市中医院河北省唐山市 063000

    赵霞, 女, 1979-01-08生,河北省沙河市人, 汉族,河北医科大学消化内科在读硕士研究生,主要研究方向为慢性肝病肝纤维化.

    通讯作者: 姚希贤, 050000, 河北省石家庄市,河北医科大学第二医院消化病研究所. zhaoxia_0108@163.com

    电话: 0311-87222831

    收稿日期: 2005-09-21 接受日期: 2005-12-10

    Yigankang inhibits proliferation of hepaticstellate cells and expression of TIMP-1 mRNA induced by interleukin-1 b

    Xia Zhao, Xi-Xian Yao, Ya-Ping Zhang,Wen-Ming Zheng

    Xia Zhao, Xi-Xian Yao, Ya-Ping Zhang,Department of Digestology, the Second Hospital of Hebei MedicalUniversity, Shijiazhuang 050000, Hebei Province, China

    Wen-Ming Zheng, Tangshan TraditionalChinese Medical Hospital, Tangshan 063000, Hebei Province, China

    Correspondence to: Xi-Xian Yao, Department of Digestology,the Second Hospital of Hebei Medical University, Shijiazhuang 050000,Hebei Province,China. zhaoxia_0108@163.com

    Received: 2005-09-21 Accepted: 2005-12-10

    Abstract

    AIM:To investigate the effects of the blood-activating andstasis-eliminating traditional Chinese medicines (TCM), including Yigankang,small compound of Radix Salviae Miltiorrizae (scRSM), and Radix SalviaeMiltiorrizae (RSM), on the proliferation of rat hepatic stellate cells(HSCs) and expression of tissue inhibitor of matrix metalloproteinase-1(TIMP-1) mRNA induced by interleukin-1b(IL-1b)..

    METHODS:The activated rat HSCs were cultured in vitroand then randomly divided into 8 groups, named A, B, C, D, E, F, G, and H.The rats in group A served as the controls, and those in the rest groupswere treated IL-1b (10 mg/L),IL-1b (10 mg/L)plus Yigankang (2 g/L), IL-1b(10 mg/L) plus scRSM (2 g/L), IL-1b(10 mg/L) plus RSM (2 g/L), RSM (2g/L), scRSM (2 g/L), and Yigankang (2 g/L), respectively. Theproliferation of HSCs was detected by cell counting kit-8 (CCK-8) and theexpression of the TIMP-1 mRNA was detected by semi-quantitative reversetranscription chain reaction (RT-PCR) ......

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