关键词: 活血祛瘀剂;异丙肾上腺素;心肌;大鼠

    摘 要:目的 研究中药复方制剂活血通脉片(Huoxue Tongmai tablet，HXTMT)对异丙肾上腺素(isoproterenol，ISO)心肌损伤大鼠的保护作用. 方法 用HXTMT给SD大鼠连续灌胃14d，第12日起动物sc ISO(48μmol·kg-1 ·d-1 )，每日一次，连续3d，复制异丙肾上腺素性心肌损伤大鼠模型. 结果 中药复方制剂HXTMT能明显减轻心肌损伤程度，血清CK活性、心肌MDA含量、心肌含水量分别减少14%，25%，2%，与模型组比较有显著性差异(P<0.05). 结论 HXTMT能稳定细胞膜、减轻心肌水肿程度、阻止脂质过氧化物的形成，提示HXTMT对心肌缺血性损伤有细胞保护作用.

    Protective effects of Huoxue Tongmai tablet on iso┐proterenol┐induced myocardial injury in rats

    LONG Yin LONG Mei LIU Li XIA Tian WANG Zong-Ren MA Shi-Ping MEI Qi-Bing YAN Pei-Song

    1 Department of Traditional Chinese Medicine，Xi-jing Hospital，

    3 Department of Pharmacology，Fac-ulty of Preclinical Medicine，

    4 Department of Pathol-ogy，Xijing Hospital，Fourth Military Medical Uni-versity，Xi'an710033，China，

    2 Department of Greiatrics，Friendship Hospital，Yili Autonomous Prefeture，Xinjiang835000

    Keywords:blood act stasis remove agents;isoproterenol;myocardium;rats

    Abstract:AIM To study protective effects of Huoxue Tongmai tablet(HXTMT) ......