关键词: 双诺希胶囊;高脂血症;胆固醇;三酰甘油;大鼠

    摘 要:目的 验证双诺希胶囊(SHNX)对高脂血症大鼠血脂的影响. 方法 用高脂饲料喂饲大鼠建立高脂血症模型;随机分为6组，即正常对照组、高脂模型组、SHNX大剂量组(SHNXH 1.200g·kg-1 )、SHNX中剂量组(SHNXM 0.600g·kg-1 )、SHNX小剂量组(SHNXL 0.300g·kg-1 )和安妥明组(Clofibrate)，连续喂饲并灌胃给药30d后，观察SHNX对高脂血症大鼠血脂含量的影响. 结果 SHNX能明显降低血清总胆固醇(TC)、三酰甘油(TG)含量，亦能明显提高血清高密度脂蛋白亚组分Ⅱ胆固醇(HDL2 -C)及高密度脂蛋白胆固醇(HDL-C)的含量. 结论 SHNX对血脂紊乱大鼠有明显的治疗效果.

    Shuangnuoxi capsule and experimental hyperlipi┐demia in rats

    HE Jian-Rong CHEN Jian-Feng LIU De-Qiang

    1 Department of Pharmacy，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China，

    2 Shaanxi Cardio-Cerbrovascular Disease In-stitute，Xi'an710004，China

    Keywords:Shuangnuoxi capsule;hyperlipidemia;choles-terol;triglyceride;rats

    Abstract:AIM To verify the effect of Shuangnuoxi capsule(SHNX)on blood lipid in rats suffering from hyperlipidemia.METHODS Five acute hyperlipidemia models of rats were establisthed with high fat feed ......