关键词: 肝炎，乙型;肝炎，丙型;细胞活素类;Th1/Th2

    摘 要:目的 研究Th1/Th2变化在慢性丙型肝炎发病机制中的作用. 方法 采用双抗体酶联分析法检测了20例正常人，35例慢性丙型肝炎，30例慢性乙型肝炎患者血清中的IFN-，IL-2，IL-4和IL-6的水平. 结果 慢性丙型肝炎组Th2类细胞因子(IL-4，IL-6)水平明显高于正常对照组(P<0.05)，Th1类细胞因子水平IL-2也增高(P<0.05)，然而，Th1类细胞因子IFN-水平有增加趋势，但无统计学差异(P>0.05).Th2类细胞因子水平比Th1类细胞因子水平高. 结论 Th2类细胞因子水平增高以及由此引起的Th1/Th2比值下降可能与慢性丙型肝炎的病程持续有关.

    Roles of Th1/Th2in pathogenesis of chronic hepati┐tis C

    DUAN Guo-Rong，ZHOU Yong-Xing，NIE Qing-He，JIA Zhan-Sheng，FENG Zhi-Hua，XIE Yu-Mei

    Department of Infectious Diseases，Tangdu Hospi-tal，Fourth Military Medical University，Xi'an710038，China

    Keywords:hepatitis B;hepatitis C;cytokines;Th1/Th2

    Abstract:AIM To study the roles of Th1and Th2cy-tokines in chronics HCV infection.METHODS Serum levels of Th1cytoines，interferon gamma(IFN-gammn)and inter-leukin(IL)-2，and Th2cytokines，IL-4and IL-6，were mea-sured by using enzyme-linked immunosorbent assay.Thirty-five individuals with chronic HCV infection，20healthy sub-jects as normal controls and30chronic HBV infected patients as disease controls were observed.RESULTS Th2cytokines(IL-4and IL-6)significantly increased in chronic HCV infect-ed patients compared with normal controls(P<0.05).Simi-larly ......