关键词: 抗角蛋白自身抗体;接触性皮炎;白细胞介素6;白细胞介素8

    摘 要:目的 研究同种异体抗角蛋白自身抗体(AK auto Abs)对家兔接触性皮炎模型血清IL-6，IL-8的影响. 方法 24只家兔随机分为AK auto Abs组和对照组，每组12只;AK auto Abs组im药物，剂量为5mg·kg-1 ，1次·2d-1 ，30d;对照组动物以同样方法每次注射2mL生理盐水.ELISA检测血清IL-6，IL-8水平变化. 结果 AK auto Abs组动物血清IL-6，IL-8的水平下降;对照组动物血清IL-6，IL-8的水平升高. 结论 接触性皮炎可诱导IL-6，IL-8的产生;AK au-to Abs则抑制IL-6，IL-8的产生.

    Influence of homologuous antikeratin autoantibodies on serum IL┐6and IL┐8of rabbit model of contact dermatitis

    XIA Ru-Shan，LIU Yu-Feng，LI Cheng-Xin，DANG Yu-Ping，WAN Ye-Hong，LU Tao

    Department of Dermatology，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China

    Keywords:antikeratin autoantibodies(AK auto Abs);con-tact dermatitis;interleukin6;interlerkin8

    Abstract:AIM To study the influence of homologuous an-tikeratin autoantibodies(AK auto Abs)on serum IL-6and IL-8in rabbit model of contact dermatitis.METHODS 24rabbits were randomly divided into two groups，12rabbits in each group.Animals in AK auto Abs group were intramuscu-larly injected with AK auto Abs(5mg·kg-1 )every two days for30days ......