关键词: 重症肌无力;受体，胆碱能;抗体;体感诱发电位，躯体感觉

    摘 要:目的 本研究旨在进一步探索重症肌无力(MG)患者的乙酰胆碱受体抗体(AChRab)是否对大鼠中枢神经系统(CNS)躯体感觉传导通路产生影响. 方法 从AChRab阳性的全身型MG患者血清中提取IgG，将其注入大鼠侧脑室，观察其对下肢体感诱发电位(SEP)的影响. 结果 注入大鼠侧脑室内的AChRab可致大鼠本体觉传导障碍，引起SEP异常，表现为N20 波消失或潜伏期延长. 结论 MG患者的AChRab不仅可以作用于NMJ处的AChR，而且还可以作用于CNS并引起本体觉传导障碍，进一步证明了AChRab在CNS中的病理作用.

    SEP test on model of central nervous system dys┐function with myasthenia gravis

    LIU Yu，LI Zhu-Yi，LIU Xu-Hong，TANG Li-Jun，YOU Guo-Xiong

    Department of Neurology，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China

    Keywords:myasthenia gravis;receptors，cholinergic;anti-bodies;evoked potentials，somatosensory

    Abstract:AIM To explore if circulating acetylcholine recep-tor antibodies(AChRab)presented in myasthenia gravis(MG)sera can cause dysfunction of somatosensory transmis-sion in CNS of rats.METHODS Before and after applica-tion of somatosensory evoked potential(SEP)test，AChRab purified from MG sera was injected into the lateral cere-broventricular system.RESULTS Intracerebroventricular administration of MG patient AChRab ......