关键词: 磁力学;支架;内皮缩血管肽-1;凝血酶

    摘 要:目的 观察经皮冠状动脉腔内成形术(PTCA)并磁化支架植入术(ICS)后冠状窦血浆的内皮素-1(ET-1)和凝血酶(Ⅱa)活性的动态变化. 方法 住院冠心病患者38例，随机植入磁化支架(MS)20例，非磁化支架(NMS)18例，分别于PTCA术前，ICS后，0.5，1，3和6h自冠状窦采血，观测血浆ET-1含量和Ⅱa活性. 结果 术后MS组的ET-1含量一直处于较低水平，而NMS组在术后即刻明显升高(P<0.01)，术后0.5开始下降，术后6h两组的ET-1含量均恢复到术前水平;MS组的Ⅱa活性于术后明显降低，术后6h较术前明显降低(P<0.01)，而NMS组在术后即刻虽有降低，但在术后6h已恢复到术前水平. 结论 磁化支架具有降低介入治疗术后冠状窦血浆ET-1含量和Ⅱa活性的作用.

    Intracoronary magnetic stents lower coronary sinus plasma ET┐1levels andⅡa activity in patients with coronary artery diseases

    ZHOU Ning，JIA Guo-Liang，LU An-Lin，LI Cheng-Xiang，LI Wei Jie，LI Jia-Yi，ZHANG Rong-Qing

    Department of Cardiology，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China

    Keywords:magnetics;stents;endothelin-1;thrombin

    Abstract:AIM To observe the effects of magnetic stents on coronary sinus plasma endothelin-1(ET-1)concentrations and thrombin(Ⅱa)activity in patients undergoing PTCA and intra-coronary stenting.METHODS Thirty-eight consecu-tive patients with coronary artery diseases were randomly im-planted magnetic stents(MS ......