关键词: 大鼠;脑梗死/康复;GAP-43蛋白

    摘 要:目的 研究康复训练对脑梗死大鼠脑的生长相关蛋白(GAP-43)表达的影响. 方法 SD大鼠采用光化学法制成脑梗死模型后，随机分康复组、制动组、自由组及正常组，每组大鼠在1，3，7，14，21，28d取脑组织免疫组化染色，以观察脑梗死大鼠各组不同时期脑的GAP-43表达. 结果 1，3，7，14d脑梗死周边区可见GAP-43阳性细胞，21，28d时梗死周边GAP-43阳性细胞逐渐减少，康复组较制动组在7，14d明显增加，尤以胼胝体为著. 结论 康复训练可引起损伤周边区GAP-43表达的变化，提示该区有促进神经新生枝芽的生长作用.

    Rehabilitative training and expression of GAP┐43in brain of rats

    XU Li LI Ling RAO Zhi-Ren QIOU Jian-Yong YUAN Hua WANG Jian

    1 Department of Physiotherapy&Rehabilitation，Xi-jing Hospital，

    2 Institute of Neurosciences of Chinese PLA，Fourth Military Medical University，Xi'an710033，China

    Keywords:rats;cerebral infarction/rehabilitation;GAP-43protein

    Abstract:AIM To study the expression of GAP-43in the brain of cerebral infarcted rats after rehabilitative training.METHODS Cerebral infarctions induced by photochemical injury were made on48SD rats，which were divided into4groups at random after1d:Rehabilitation group，free group，barking group and normal group.The changes of GAP-43in brain were immunohistochemically studied at1，3，7，14，21，28d after rehabilitative training.RESULTS GAP-43stained cells were found around infarcted area at1 ......