关键词: 间皮瘤;胃肠肿瘤;免疫组织化学;抗原，CD34

    摘 要:目的 探讨胃肠道间质瘤(GIST)的诊断及鉴别诊断. 方法 GIST患者50例，进行常规检查及P53 /P21 ，HHF-35，vimentin，CD34 免疫组化检测. 结果 本组50例GIST，恶性34例，交界性10例，良性6例，以胃及小肠为多发(68%).免疫组化以平滑肌细胞分化为主型占46%，神经源分化型占18%，平滑肌和神经双向分化型18%，未分化型24%.肌肉共同蛋白HHF-35为平滑肌细胞分化最敏感的标志物.未分化型间质瘤的免疫表型为vimentin和CD34 阳性.P53 蛋白和P21 蛋白对GIST的良恶性可资鉴别. 结论 尽管胃肠道间质瘤光镜下形态相似，但其免疫表型呈异源性，需要做免疫组化准确定性.

    Immunohistochemical diagnosis of gastrointestinal stromal tumors and the expression of P53 and P21

    HE Ke-Ying ，YAN Jia-Chun

    1 Department of Pathology，Second People Hospital，Bangbu233000，China，2 Department of Pathology，123Hospital of Chinese PLA

    Keywords:mesothelioma;gastrointestinal neoplasms;im-munohistochemistry;antigens，CD

    34

    Abstract:AIM To study the pathological diagnosis and dif-ferential diagnosis of gastrointestinal stromal tumor(GIST).METHODS Routine and immunohistochemical(P53 /P

    21 ，HHF-35，vimentin，CD34 )examinations were performed on50patients with GIST.RESULTS Among the50cases，34were malignant，10broadline，and6benign，and GISTs were mostly in stomach and intestine(68%).The results of im-munohistochemical examination showed that the type of smooth-muscle cell differentiation accounted for46%;neuro-genic differentiation ......