关键词: 受体;生长抑素;垂体腺瘤

    摘 要:目的 研究生长抑素受体1，2亚型在不同病理类型垂体腺瘤中的表达特性. 方法 运用原位杂交技术，以放射性核素标记SSTR1-2亚型的寡核苷酸为探针，检测29例垂体瘤、12例正常垂体组织中SSTR1，2mRNA的表达模式. 结果 SSTR1，2亚型同时表达于功能型、无功能型垂体瘤及正常垂体组织中，它们的阳性率分别为100%，79%，33%和100%，86%，25%;其中SSTR2表达的强阳性率较高(52%). 结论 垂体腺瘤可同时表达两种生长抑素受体亚型，因此它具有接受受体介导的生长抑素类似物靶向治疗的乐观前景.

    Expression of two somatostatin receptor subtypes in pituitary adenoma

    WANG Jing WANG Lian-Gang WU Sheng-Xi DENG Jing-Lan

    1 Department of Nuclear Medicine，

    2 Department of Experimental Surgery， Xijing Hospital，

    3 Department of Anatomy，Faculty of Preclinical Medicine，Fourth Military Medical University，Xi'an710033，China

    Keywords:receptor;somatostatin;pituitary adenoma

    Abstract:AIM To investigate the characteristics of expres-sion and distribution of2subtypes of somatostatin receptor(SSTR1-2)mRNA in pituitary adenoma.METHODS With [α-35 S]dATP labeled oligonucleotide of the2SSTR subtypes as probe，using in situ hybridization，patterns of mRNA ex-pression were detected in29pituitary tumor cases and12nor-mal pituitary tissues.Additionally ......