关键词: 电磁场;海马;FosB;ΔFosB;免疫组织化学

    摘 要:目的 观察经颅重复性磁刺激(rTMS)后海马ΔFosB阳性标记的变化. 方法 SD大鼠头部予以1Hz，100mT的磁刺激(美国Magstim公司)，每日一次，每次10min，共14d.最后一次刺激后24h，灌注动物并取脑，经海马冠状切片，免疫组织化学ABC法检测海马各区ΔFosB免疫阳性产物的表达. 结果 rTMS后，大鼠海马齿状回及CA1区表现出明显增多及染色增强的ΔFosB免疫阳性产物，CA2，CA3区则未出现ΔFosB免疫阳性产物;假刺激组动物仅海马齿状回表现出少许淡染的ΔFosB免疫阳性产物，CA1，CA2，CA3区则无ΔFosB免疫阳性产物出现. 结论 我们认为rTMS后ΔFosB免疫阳性产物在海马的集聚，提示rTMS可能通过影响海马长时程神经和行为塑形而发挥其治疗作用.

    Effects of repetitive transcranial magnetic stimula┐tion onΔFosB expressions in rat hippocampi

    LIN Hong LIU Yu JU Gong

    1 Department of Neurology，Tangdu Hospital，Xi'an710038，China，

    2 Institute of Neuroscience of Chi-nese PLA，Fourth Military Medical University

    Keywords:electromagnetic fields;hippocampi;FosB;ΔFosB;immunohistochemistry

    Abstract:AIM To observe the effects of repetitive transcra-nial magnetic stimulation(rTMS)onΔFosB expressions in rat hippocampi.METHODS SD rats were treated with repetitive1Hz，100m Tesla transcranial magnetic stimula-tion for14d，10minutes each day and thenΔFosB expres-sions in hippocampi were detected immunohistochemically.RESULTS High and deeply stainedΔFosB expressions were induced in hippocampi of experimental rats ......