【摘要】 目的 探讨甲磺酸多沙唑嗪治疗原发性轻、中度高血压的临床疗效及不良反应。方法 200例高血压患者随机分成两组，甲磺酸多沙唑嗪组(治疗组，100例)2～8mg/d口服，疗程4周；特拉唑嗪组(对照组，100例)2～8mg/d口服，疗程4周。治疗前后检查记录血压、心率、肝肾功能、血脂、离子、血尿常规。结果 治疗组总有效率为83.00%，降压幅度收缩压(SBP)下降10.86%，舒张压(DBP)下降12.29%；对照组总有效率78.00%，降压幅度SBP下降11.35%，DBP下降13.09%。两组结果统计分析，P>0.05，差异无显著性。两组药物对患者肝肾功能及血离子无影响。治疗组不良反应发生率21.00%，主要为头晕、头痛，皆较轻微，不影响继续用药。有效剂量为2～8mg/d。结论 甲磺酸多沙唑嗪治疗高血压疗效确切，不良反应少，推荐剂量为2～8mg/d。

    【关键词】 甲磺酸多沙唑嗪；特拉唑嗪；高血压；治疗

    Clinical efficacy of doxazosin mesylate for the treatment of primary hypertension

    BAI Xiu-ping,LI Xue-qi,GUAN Zhen-zhong.

    Department of cardiology of the Second Affiliated clinical Hospital,Harbin Medical University,Heilongjiang 150086,China

    【Abstract】 Objective To explore the clinical efficacy and adverse effects of doxazosin mesylate (Dox) for the treatment of mild to moderate hypertension. Methods A total of 200 patients with mild to moderate hypertension were randomly treated with either Dox (2-8 mg perday,oo.dally ......