全反式维甲酸_

全反式维甲酸对糖尿病大鼠尿转化生长因子β1排泄率及肾小球病变的影响

http://www.100md.com 《西安交通大学学报》 2005年第5期

全反式维甲酸,,全反式维甲酸；糖尿病肾病；转化生长因子β1；大鼠；链尿佐菌素,1材料与方法,2结果,3讨论,参考文献

     摘要：目的观察全反式维甲酸(alltransretinoic acid, atRA)对链尿佐菌素(STZ)诱导的糖尿病大鼠早期肾小球病变的保护作用。方法 20只雄性SD大鼠分糖尿病维甲酸治疗组、糖尿病对照组和正常对照组。糖尿病维甲酸治疗组每天给予全反式维甲酸10mg/kg体质量皮下注射，共7d(n=6)。检测尿蛋白和转化生长因子β1(TGFβ1)的排泄率、血清、尿液及肾组织一氧化氮(NO)水平和肾脏病理变化。结果糖尿病对照组尿蛋白及TGFβ1排泄率、血清、尿液及肾组织NO水平和肾小球基质比例明显高于正常对照组，全反式维甲酸则减轻了这些变化。结论全反式维甲酸具有延缓糖尿病肾小球病变进展的作用，这种作用可能与抑制TGFβ1和NO的分泌有关。

    关键词：全反式维甲酸；糖尿病肾病；转化生长因子β1；大鼠；链尿佐菌素

    Effect of alltrans retinoic acid on the excretion of urine TGFβ1

    and glomerular lesion of diabetic rat

    Zhu Dan, Gui Baosong, Yao Ganglian, Gao Dengfeng, Ning Ning, Zhang Hongli

    (1. Department of Nephrology; 2. Department of Cardiology, Second Hospital

    of Xian Jiaotong University, Xian 710004, China)

    ABSTACT: Objective To investigate the effect of alltrans retinoic acid(atRA) on the urinary TGFβ1 excretion and glomerular lesion of diabetic rats at early stage. Methods SD rats were randomly assigned into 3 groups: atRA treated group, diabetic control group and normal control group. Streptozotocin(STZ)induced early diabetic male SD rat were used. The atRA treated group were treated with daily subcutaneous injections atRA of 10mg/kg for 7 days (n=6), and then the excretion of urinary protein and TGFβ1 and NO level of plasma, urine and renal tissue were measured, and pathological changes of their kidneys were observed. Results The diabetic control rats showed increased urinary excretion of protein and TGFβ1 and NO level of plasma, urine and renal tissue and deposit of glomerular matrix, while atRA prevented these changes. Conclusion AtRA can prevent the development of diabetic nephropathy, which is relevant with the inhibition of secretion of TGFβ1 and NO. ......

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