【摘要】 目的 探讨腹腔镜胆囊切除手术后静脉注射昂丹司琼对术后恶心呕吐的预防疗效。方法 90例ASAⅠ～Ⅱ级，择期腹腔镜胆囊切除术患者随机分成3组。第Ⅰ组对照组，术后给予生理盐水5ml。第Ⅱ组氟哌利多组，术后静注氟哌利多1.25mg。第Ⅲ组术后静注枢复宁4mg。观察术后24h患者的恶心呕吐情况。结果 第Ⅰ、Ⅱ、Ⅲ组患者恶心呕吐发生率分别为60.0%、30.0%、26.7%。第Ⅱ组与第Ⅰ组之间差异有显著性(P<0.05)，第Ⅲ组与第Ⅰ组之间差异有非常显著性(P<0.01)。第Ⅱ组与第Ⅲ组之间差异无显著性(P>0.05)。结论 本研究示术毕时静脉注射昂丹司琼4mg与氟哌利多1.25mg均能有效防止、预防腹腔镜术后恶心呕吐。

    【关键词】 术后恶心呕吐；昂丹司琼

    【Abstract】 Objective To evaluate the prophylactic efficacy of ondansetron on postoperative nausea and vomiting on the laparoscopic cholecystectomy(LC).Methods In a prospective,randomized,single blind placebo controlled trial,90 patients of ASA Ⅰ-Ⅱ scheduled for LC were received one three regimens:placebo group (group 1 physiological saline 5 ml),droperidol group (group 2,droperidol 1.25 mg),ondensetron group(group 3,ondansetron 4 mg).Patients were followed for 24hr with regards to PONV after surgery.Results It had significant difference between group 2 and group 1(P<0.05),it had significant difference between group 3 and group 1 (P<0.01),it had not significant difference between group 2 and group 3(P>0.05).At 24hr,PONV rate was 60% in group 1,30% in group 2,26.7% in group 3.Conclusion Odansetron is as effective as droperidol in the prevention of PONV for the patients undergoing laparoscopic cholecystectomy(LC). ......