关键词: 庆大霉素类;中毒;听力障碍;水杨酸;药物相互作用

    中图号:R764.6

    摘 要:目的 探讨水杨酸钠(sodium salicylate，NaSA)对庆大霉素(gentamicin，GM)耳毒性作用的影响及其机制. 方法 豚鼠随机分为对照组、GM组、NaSA组和GM+NaSA组，每组9只.采用听性脑干反应(acoustic brainstem re-sponse，ABR)、耳蜗铺片及透射电镜技术，观察用药前后听反应阈及形态变化，检测血清尿素氮、肌苷以及GM浓度，同时测定组8kHz ABR平均阈移达55dB，GM+NaSA组平均阈移为23dB，差异显著(P<0.05).形态学改变与听力变化一致.GM+NaSA组耳蜗组织丙二醛和铁离子较GM组明显减少(P<0.05)，GM+NaSA组和GM组超氧化物歧化酶活性明显高于另两组(P<0.05)，GM+NaSA组和NaSA组前列环素水平显著低于另两组(P<0.05).NaSA对GM血药浓度没有影响. 结论 自由基和铁离子在GM的耳毒性中起重要作用，NaSA能有效减轻GM耳毒性，有望成为临床庆大霉素耳毒性的预防药物.

    Sodium salicylate protects against gentamicin oto-toxicity

    WANG Jin-Ling，HUANG Wei-Guo，CHEN Yang，LIU Shun-Li

    Department of Otorhinolaryngology，Xijing Hospi-tal，Fourth Military Medical University，Xi'an710033，China

    Keywords:gentamicins;poisoning;hearing disorders;sali-cylic acid;drug interactions

    Abstract:AIM To study the prevention of gentamicin(GM)ototoxicity by sodium salicylate(NaSA)in the guinea pig.METHODS Guinea pigs were randomly assigned to three experimental groups(GM-treated alone，NaSA-treated alone，GM and NaSA in combination)and one control group.Acoustic brainstem response(ABR) ......