[摘要] 目的: 验证战伤喷剂在创伤早期抗感染的效果，以及战伤喷剂对战创伤感染发生的影响。 方法: 采用烫伤合并人工感染绿脓杆菌的家兔模型，用战伤喷剂与溶剂组于实验前和实验后第1、2、4、7、14天采集家兔血清，测量体温，检测白细胞数、血清NO 2- /NO 3- 水平、血清肿瘤坏死因子水平、血清超氧阴离子等炎性因子水平以及谷丙转氨酶、碱性磷酸酶、天冬氨酸转移酶、肌苷和尿素氮等肝肾功能指标水平。 结果: 实验组药效学检测指标的升高比对照组缓慢，最终2组均达到较高的感染发生指标;器官功能的安全性指标无明显变化，且2组变化大致相同。 结论: 战伤喷剂在创伤早期应用可以有效延迟创伤感染的发生，但并不能阻止感染的发生或减轻感染的程度。

    [关键词] 战伤喷剂;感染;炎性指标;药效学;烫伤

    Research on pharmacodynamics and safety of the combat trauma spray in the treatment of skin scald with complications in rabbits

    BA Jian-bo，XU Xiong-li，CHEN Shuang-hong，et al

    (Naval Medical Research Institute，Shanghai200433，China)

    Abstract:Objective:To demonstrate the effect of the combat trauma spray on anti-infection in the early stage of trauma，as well as infection occurrence following trauma.Methods:A rabbit model was developed with scald complicated with artificial infection of Pseudomonas aeruginosa.Studies were carried out by using the combat trauma spray group and the solution group.At day1，2，4，7，14，post experiments，rabbit serum was collected，the body temperatures of animals were taken，and such inflammatory factors as white cell count ......