Preventive effects and mechanism of Qidantongmai tablet on isoproterenol caused chronic myocardial infarction in mice

    LI Jingª²Hua, WANG Zongª²Ren, XIAO Tieª²Hui, SHAO Zhongª²Jun, MA Jing, ZHENG Jin, MA Aiª²Ling, LONG Yin, WANG Wen, LI Junª²Chang

    Department of Traditional Chinese Medicine, Xijing Hospital, 2Department of Epidemiology, Faculty of Preventive Medicine, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To investigate the preventive effects of Qidantongmai tablet on chronic myocardial infarction in mice and its possible mechanism. METHODS: Wistar mice were given small-dose of Qidantongmai Tablet to see the preventive effects on isoproterenol (ISO) caused chronic myocardial infarction, and the contents of VEGF and bFGF in the part of ischemia were detected by immunohistochemistry method to explore its mechanism. RESULTS: No expression of VEGF and bFGF was found in the group of non-injection ISO, but in ISO injection groups QiDanTongMai Tablet enhanced the expression of VEGF and bFGF. CONCLUSION: Qidantongmai tablet can prevent chronic myocardial ischemia and the acceleration of the expression of VEGF and bFGF may be responsible for it. ......