肾康注射液对肾小球系膜细胞增殖及自分泌FN的效应
肾康注射液,,肾康注射液;肾小球系膜细胞;纤维连接蛋白,0引言,1材料和方法,2结果,3讨论,【参考文献】
Effect of Shenkang injection on proliferation of glomerular mesangial cellLI Feng, WANG HanMin, HANG Li, WANG ChangHai, CHENG QingLi,YE ChuanHui
Department of Traditional Chinese Mendicine, Xijing Hospital, Fourth Military Medical University, Xian 710033, China, Department of Nephrology,General Hospital of Chinese PLA, Beijing 100853, China, Department of Nephrology, Affiliating Hospital,Chengdou University of Traditional Chinese Mendicine, Chengdou 610075, China
【Abstract】 AIM: To explore the mechanism of ShenKang Injection (SKI) on prohibiting glomerulosclerosis (GS) so as to provide fresh evidence for clinical application of SKI in treating chronic renal failure (CRF). METHODS: Using serumpharmacological test of Chinese herbs, the effects of SKI on the proliferation in cultured human glomerular mesangial cells (GMC) and the level of fibronectin (FN) secretion in cultured GMC were observed. RESULTS: SKI and serum with SKI significantly inhibited the proliferation and the level of secreting FN in cultured GMC in a concentrationdependent manner (P<0.01, P<0.05). With the prolonging of stimulating time, the inhibitory effects SKI increased on the proliferation and the level of FN, but the effects of serum with SKI decreased on the proliferation and the level of FN. CONCLUSION: The effects of SKI on GMC differ from those of serum with SKI. It is indicated that the effective mechanism of SKI is complicated and is related to SKI metabolism. ......
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