maspin、p27、skp2在大肠肿瘤的表达及意义
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刘丹丹, 易永芬, 邓 玮
结直肠肿瘤;maspin;p27;skp2;免疫组织刘丹丹,易永芬,邓玮.maspin、p27、skp2在大肠肿瘤的表达及意义. 世界华人消化杂志2006;14(3)267-272masp
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刘丹丹,易永芬, 邓玮,重庆医科大学病理教研室 重庆市 400016
刘丹丹, 女, 1980-05-28生,四川省彭州市人, 汉族, 2003年重庆医科大学硕士研究生在读,主要从事消化系统肿瘤方向的研究.
重庆市教委资助项目, No. 040310
通讯作者: 易永芬, 400016, 重庆市医学院路1号, 重庆医科大学病理科.
收稿日期:2005-11-08 接受日期: 2005-11-24
Expression and its significance of maspin, p27 and skp2 in colorectal cancer
Dan-Dan Liu, Yong-Fen Yi, Wei Deng
Dan-Dan Liu, Yong-Fen Yi, Wei Deng, Department of Pathology, Chongqing University of Medical Science, Chongqing 400016, China
Supported by the Fund from Chongqing Committee of Education, No.040310
Correspondence to: Yong-Fen Yi, Department of Pathology, Chongqing University of Medical Science, Chongqing 400016, China
Received: 2005-11-08 Accepted: 2005-11-24
Abstract
AIM: To explore the expression of maspin, p27, skp2 in colorectal adenocarcinoma as well as their roles in the tumorgenesis and progression of colorectal carcinoma.
METHODS:SP immunohistochemistry was used to detect the expression of maspin, p27 and skp2 in tissues of colorectal tubular adenocarcinoma (n = 30), colorectal polypous adenoma (n = 20) and normal controls (n = 20).
RESULTS:Of 30 cases of tubular adenocarcinoma, the positive rates of maspin, p27 and skp2 expression were 83.3%(25/30), 50%(15/30), and 36.7%(11/30), respectively; of 20 cases of polypous adenoma, the positive rates of maspin, p27 and skp2 were 95%(19/20), 80%(16/20), and 10%(2/20), respectively; of 20 cases of normal colorectal tissues, the corresponding positive rates were 95%(19/20), 90%(18/20), and 5%(1/20). The expression of maspin was significantly correlated with lymph node metastasis (P = 0.04) and Duke’s staging (P = 0.014). The expression of p27 and skp2 showed a marked correlation with the differentiation of carcinoma (P = 0.014, P = 0.001), while no significant correlation with tumor infiltration depth, lymph node metastasis and Duke’s staging ......
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