肿瘤坏死因子相关凋亡诱导配体受体DR4在大肠癌的表达及意义
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闫庆辉, 张国建, 任鹏涛, 赵 晶, 王凤安
大肠癌;DR4;免疫组化;流式细胞分析闫庆辉,张国建,任鹏涛,赵晶,王凤安.肿瘤坏死因子相关凋亡诱导配体受体DR4在大肠癌的表达及意义.世界华人消化杂志2006;14(3)332-335http,w
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闫庆辉, 张国建, 任鹏涛, 赵晶, 王凤安, 河北医科大学第二医院胃肠外科 河北省石家庄市 050000
河北省卫生厅科学基金资助项目, No.2004014
通讯作者:王凤安, 050000, 河北省石家庄市和平西路215号, 河北医科大学第二医院胃肠外科. galaxy@sina.com
电话: 0311-87222983
收稿日期: 2005-11-23 接受日期: 2005-12-08
Expression and significance of TNF-related apoptosis-inducing ligand receptor DR4 in large intestine carcinoma
Qing-Hui Yan, Guo-Jian Zhang, Peng-Tao Ren, Jing Zhao, Feng-An Wang
Qing-Hui Yan, Guo-Jian Zhang, Peng-Tao Ren, Jing Zhao, Feng-An Wang, Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
Supported by the Science Foundation from Health Department of Hebei Province, No. 2004014
correspondence to: Dr. Feng-An Wang, Department of Gastrointestinal Surgery, the Second Affiliated Hospital of Hebei Medical University, 215 Heping West Road, Shijiazhuang 050000, Hebei Province, China. galaxy@sina.com
Received:2005-11-23 Accepted:2005-12-08
Abstract
AIM: To explore the expression of TNF-related apoptosis-inducing ligand (TRAIL) receptor DR4 in large intestinal carcinoma and its correlation with clinical pathological characteristics.
METHODS: SP immunohistochemical technique and flow cytometry were used to detect the expression of DR4 in 41 cases of large intestinal carcinoma and 9 cases of normal tissues.
RESULTS: The positive cell membrane and cytoplasmic expression were observed in large intestinal carcinoma and normal large intestine mucosal tissues. Of large intestinal carcinoma, DR4 was positively expressed in 65.85%. However, the positive rate of DR4 in the normal tissues was 22.20%, which was significant lower than that in the cancer tissues (P <0.05). The fluorescence index (FI) of DR4 protein in the normal mucosal tissues was 1.00±0.13, while that in the cancer tissues was 1.17±0.13. There was significant difference between them (P <0.05). DR4 expression in the cancer tissues was not correlated with the degree of differentiation and lymph node metastasis ......
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