瑞巴派特对门脉高压性胃病胃黏膜中瘦素表达的影响
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徐可树, 李 琪, 周 霞
瑞巴派特;瘦素;门脉高压性胃病徐可树,李琪,周霞.瑞巴派特对门脉高压性胃病胃黏膜中瘦素表达的影响. 世界华人消化杂志2006;14(3)346-349 RT-PCR法检测瑞巴派
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徐可树,李琪, 周霞, 华中科技大学同济医学院附属协和医院消化内科 湖北省武汉市 430022
通讯作者: 徐可树, 430022, 湖北省武汉市, 华中科技大学同济医学院附属Ð和医院消化内科. xuzou@medmail.com.cn
电话: 027-67119890
收稿日期: 2005-12-08 接受日期: 2005-12-31
Influence of Rebamipide on leptin expression in gastric mucosa with portal hypertensive gastropathy
Ke-Shu Xu, Qi Li, Xia Zhou
Ke-Shu Xu, Qi Li, Xia Zhou, Department of Digestive Disease, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Correspondence to: Dr. Ke-Shu Xu, Department of Digestive Disease, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China. xuzou@medmail.com.cn
Received: 2005-12-08 Accepted: 2005-12-31
Abstract
AIM: To investigate the influence of Rebamipide on the expression of leptin in gastric mucosa with portal hypertensive gastropathy, and to evaluate its role in the prevention of gastric mucosal injury.
METHODS: Thirty healthy subjects and thirty patients were involved in this study. The former were randomized into normal control and normal intervention group, and the latter into blank control and trial group (15 for each). Normal intervention and trial group were treated with Rebamipide. Endoscopy was performed and the level of leptin mRNA expression in gastric mucosa was examined by reverse transcription polymerase chain reaction (RT-PCR) before and after the treatment.
RESULTS: At baseline, the expression of leptin mRNA was significantly higher in blank control and trial group than that in normal control group (0 ......
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