【摘要】 目的 客观观察和评价甲状腺素治疗重症充血性心力衰竭(CHF)的临床疗效及治疗的可行性。方法 对122例符合条件的CHF住院病人采取随机分组试验的方法。小剂量、短疗程间歇使用甲状腺素，从临床心功能改善、血流动力学、再入院率等方面对两组进行观察比较。结果 对照组和治疗组在心功能改善总有效率、显效率分别为76.6%、28.3%，87%、38.7%，改善时间分别为62.8h和42.6h。外周血管阻力，射血分数上均显示出差异有显著性(P<0.05)。随访期内再入院率明显下降。治疗组无任何副作用发生。结论 小剂量、短疗程，间歇给药，使用甲状腺素补充性治疗，对重症及顽固性心衰的效果明显，且能明显降低病人的再入院率，减少医疗费用。

    【关键词】 充血性心力衰竭；甲状腺激素

    Clinical study on the therapeutic effect of thyroxin to congestive heart failure

    LI Zong-wei,YU Chang-chun,YIE Mei,et al.

    Xixian People's Hospital,Henan 464300,China

    【Abstract】 Objective To investigate the clinical effect and therapeutic feasibility of thyroxin to congestive heart failure(CHF).Methods 122 cases of CHF patient were divided into two groups randomly. The control group were treated by routine treatment, and the treatment group by thyroxin in addition to routine treatment. The changes of cardiac function and hemodynamic of the two groups were compared.Results The effective improvement rate of cardiac function for the control and treatment groups were 76.6% and 28.3%, and 87% and 38.7%, and the improvement time were 62.8h and 42.6h respectively. The peripheral vascular resistance and ejection fraction (EF) were improved significantly in the treatment groups (P<0.05).And no side effect was observed in the treatment group. Conclusion It is effective and feasible to treat CHF, especially for severe and refractory cases, using thyroxin in small dose and short course. ......