血管生成素 -2 与基质金属蛋白酶 -7 在大肠癌中的表达及意义
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李 霞, 朱尤庆, 罗 峻, 陶文惠, 黄 超,
血管生成素-2;基质金属蛋白酶-7;大肠癌,血管生成素-2与基质金属蛋白酶-7在大肠癌中的表达及意义,李霞,朱尤庆,陶文惠,黄超,张金梅,罗峻,通讯作者:,Clinicalsignificance
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李霞, 朱尤庆, 陶文惠, 黄超, 张金梅, 武汉大学中南医院消化内科 湖北省武汉市 430071
罗峻, 武汉大学中南医院病理科 湖北省武汉市 430071
通讯作者: 朱尤庆, 430071, 湖北省武汉市, 武汉大学中南医院消化内科. uqing_zhu@sina.com.cn
电话: 027-67813072
收稿日期: 2005-12-01 接受日期: 2005-12-19
Clinical significance and expression of angiopoietin-2 and matrix metalloproteinase-7 in human colorectal carcinoma
Xia Li, You-Qing Zhu, Jun Luo, Wen-Hui Tao, Chao Huang, Jin-Mei Zhang
Xia Li, You-Qing Zhu, Wen-Hui Tao, Chao Huang, Jin-Mei Zhang, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China
Jun Luo, Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China
Correspondence to: Dr. You-Qing Zhu, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, Hubei Province, China. uqing_zhu@sina.com.cn
Received: 2005-12-01 Accepted: 2005-12-19
Abstract
AIM: To investigate the expression of angiopo-ietin-2 (Ang-2) and matrix metalloproteinase-7 (MMP-7) protein in human colorectal carcinoma, and to explore the relationship between the two proteins and clinical parameters.
METHODS: Immunohistochemical technique was used to detect the expression of Ang-2 and MMP-7 protein in 40 colorectal carcinoma and their adjacent normal tissues.
RESULTS: The positive rates of Ang-2 and MMP-7 were significantly higher in colorectal carcinoma than those in normal tissues (77.5% vs 40%, P = 0.001; 85% vs 35%, P = 0.000). The level of Ang-2 expression had no marked correlations with the sex and age of patients as well as the site, size, lymph node metastasis or histological differentiation of colorectal carcinoma (all P > 0.05), but it was notably correlated with the invasion depth (P = 0.007), distal metastasis (P = 0.023) and Dukes’ staging (P = 0.008). The expression of Ang-2 and MMP-7 were also significantly correlated (P = 0 ......
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