血小板活化因子受体拮抗剂对幼年大鼠肠黏膜上皮细胞间紧密连接蛋白的影响
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王丽杰, 刘春英, 许玲芬, 高 红, 姜卫国,
血小板活化因子;受体拮抗剂;屏障;紧密连接;ZO-1,王丽杰,许玲芬,孙梅,刘春英,高红,姜卫国,王丽杰,通讯作者:,E
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王丽杰, 许玲芬, 孙梅, 中国医科大学附属第二临床学院儿科 辽宁省沈阳市 110004
刘春英, 解放军463医院儿科 辽宁省沈阳市 110042
高红, 中国医科大学附属第二临床学院中心实验室 辽宁省沈阳市 110004
姜卫国, 中国医科大学附属第二临床学院病理科 辽宁省沈阳市 110004
王丽杰, 女, 1968-11-26生, 辽宁省本溪市人, 汉族, 2001年中国医科大学硕士, 目前中国医科大学博士研究生在读, 副主任医师, 主要从事儿科危重症、胃肠功能障碍的研究.
通讯作者: 孙梅, 王丽杰, 110004, 沈阳市和平区三好街36号, 中国医科大学附属第二临床学院儿科. wlj682002@sohu.com.cn
电话: 024-23255060 传真: 024-83955509
收稿日期: 2005-12-20 接受日期: 2006-01-07
Effect of platelet activating factor receptor antagonist on tight junction associated protein between epithelial cells of intestinal mucosa in young rats
Li-Jie Wang, Chun-Ying Liu, Ling-Fen Xu, Hong Gao, Wei-Guo Jiang, Mei Sun
Li-Jie Wang, Ling-Fen Xu, Mei Sun, Department of Pediatrics, the Second Affiliated Clinical College of China Medical University, Shenyang 110004, Liaoning Province, China
Chun-Ying Liu, Department of Pediatrics, the 463 Hospital of Chinese People’s Liberation Army, Shenyang 110042, Liaoning Province, China
Hong Gao, Central Laboratory, the Second Affiliated Clinical College of China Medical University, Shenyang 110004, Liaoning Province, China
Wei-Guo Jiang, Department of Pathology, the Second Affiliated Clinical College of China Medical University, Shenyang 110004, Liaoning Province, China
Correspondence to: Mei Sun, Li-Jie Wang, Department of Pediatrics, the Second Affiliated Clinical College of China Medical University, 36 Sanhao street, Heping District, Shenyang 110004, China. wlj682002@sohu.com.cn
Received: 2005-12-20 Accepted: 2006-01-07
Abstract
AIM: To investigate the effect of platelet acti-vating factor (PAF) receptor antagonist on the tight junction associated protein ZO-1 (zonula occludens-1) between epithelial cells of intestinal mucosa in young rats.
METHODS: Eighteen day-old Wistar rats were randomly assigned into lipopolysaccharide (LPS) group, PAF receptor antagonist (prevention and treatment) group and control group ......
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