埃索美拉唑对十二指肠球溃疡合并幽门螺杆菌感染的治疗
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谢玉民
埃索美拉唑;十二指肠球溃疡;幽门螺杆菌;法莫替丁;疗效,谢玉民,通讯作者:,EfficacyofEsomeprazoleintreatmentof
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谢玉民, 首都医科大学附属北京天坛医院消化内科 北京市 100050
通讯作者: 谢玉民, 100050, 北京市崇文区天坛西里6号, 天坛医院消化内科. yuer2010@hotmail.com
电话: 010-63057173
收稿日期: 2005-10-20 接受日期: 2005-12-31
Efficacy of Esomeprazole in treatment of duodenal ulcer complicated with Helicobacter Pylori Infection
Yu-Min Xie
Yu-Min Xie, Department of Gastroenterology, Tiantan Hospital, Beijing 100050, China
correspondence to: Yu-Min Xie, 6 Tiantan West Road, Chongwen District, Beijing 100050, China. yuer2010@hotmail.com
Received: 2005-10-20 Accepted: 2005-12-31
Abstract
AIM: To observe the effects of Esomeprazole plus Lifuxing plus Clarithromycin in the treatment of duodenal ulcer complicated with Helicobacter Pylori infection.
METHODS: Sixty-four patients with duodenal ulcer, who were positive for H Pylori (H Pylori), were randomly assigned to group A (n = 32) and B (n = 32). The patients in group A were treated with Esomeprazole (40 mg) plus Lifuxing (0.2 g) plus Clarithromycin (0.5 g), while those in group B were treated with Famotidine (20 mg) plus Lifuxing (0.2 g) plus Clarithromycin (0.2 g). At the end of treatment, the cure rate of duodenal ulcer and the rate of H Pylori eradication as well as the improvement of clinical symptoms were analyzed.
RESULTS: The cure rates of the patients were 100% and 81.3% in group A and B, respectively, and there was significant difference between them (P < 0.01). The rate of H Pylori eradication were 90.6% and 71.9% in group A and B, respectively, and there also exists significant difference between them (P < 0 ......
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