次声诱导的大鼠心肌细胞凋亡和血管内皮损伤
心肌,细胞学,,次声;大鼠;,心肌,细胞学;脱噬作用;内皮,血管,0引言,1材料和方法,2结果,3讨论,【参考文献】
Effects of infrasound on rat cardiac cell apoptosis and vascular endothelia damagePEI ZhaoHui, CHEN JingZao, ZHU MiaoZhang, TAN YongXia, ZHANG Qiang
1Department of Physiology, School of Basic Medicine, 2Department of Rehabilitation & Physiotherapy, Xijing Hospital, Fourth Military Medical University, Xian 710033, China, 3PLA Institute of Orthopaedics Oncology, Tangdu Hospital, Fourth Military Medical University, Xian 710038, China
【Abstract】 AIM: To observe the changes of cardiac cell apoptosis and vascular endothelia damage of the rats in treating groups exposed to infrasound with 8 Hz of 130 dB. METHODS: Using infrasound, the rats were exposed for 0, 7, 14, 21, and 28 d, 2 h daily,then the apoptosis protein Bax、Bclx and ET1, NO were measured after exposure. RESULTS: After exposure of infrasound, The expression of Bax and Bclx in treating groups compared with the control group was significantly increased with time (P<0.01). The increasing expression of bclx compared with that of bax was statistically declined with time. The changes of ET1 contents in rat plasma: All groups were increased (P<0.01), mostly at 7 d, more at 21 d and 28 d than at 14 d, least at 14 d. After exposure of infrasound, the change of NO contents in plasma: NO contents in rat plasma declined significantly at 7 d (P<0.05) and 14 d (P<0.01), then 0, 21 and 28 d normally (P>0.05). CONCLUSION: Infrasound can induce the cardiac cell apoptosis and damage the vascular endothelia. These changes depend on the amounts of infrasound and time exposed to. ......
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