Study on expression and clinical significance of selenoproteinª²P in hepatocellular carcinoma by tissue microarray technique

    NING Li, MA Qingª²Jiu, LANG Bing, YAN Wei, LU Jianª²Guo, LAI Daª²Nian, YANG Jianª²Guo, LIN Chen

    1Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi¡¯an 710038, China, 2Department of Neurobiology, School of Basic Medicine, 3Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi¡¯an 710033, China, 4National Laboratory of Molecular Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China

    ¡¾Abstract¡¿ AIM: To study the expression of selenoproteinª²P (Seª²P) in hepatocellular carcinoma (HCC) and its significance in clinical pathology. METHODS: Seª²P expression was detected in 84 cases of HCC tissues and 60 cases of normal liver tissues with polyclone antibody by tissue microarrys and immunohistochemistry. The results were compared with clinicopathologic grades. RESULTS: The positive expression rates of Seª²P in HCC and normal liver tissues were 77.4% (65/84) and 95.0% (57/60), respectively, showing significant statistical difference (P<0.05). The Seª²P expression was correlated to the Child Classification. But, no correlation was found between Seª²P expression level, the TNM classification and the Edmondson grade. CONCLUSION: Seª²P may play an important role in the carcinogenesis of HCC. The expression level of Seª²P in HCC tissues may serve as a clinicopathologic index for the hepatic function and prognosis of HCC. ......