肝细胞癌__(期刊论文)

人肝癌组织中EGF，TGFα及其受体EGFR mRNA的表达

http://www.100md.com 《第四军医大学学报》 2004年第9期

肝细胞癌,,肝细胞癌；表皮生长因子；转化生长因子α；表皮生长因子受体；逆转录聚合酶链反应,人肝癌组织中EGF，TGFα及其受体EGFRmRNA的表达,0引言,1材料和方法,2结果,3讨论

     Expression of EGF, TGFα and EGFR mRNA in human hepatocellular carcinoma

    TAO KaiShan, DOU KeFeng

    Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710033, China

    【Abstract】 AIM: To investigate the roles of epidermal growth factor (EGF), transforming growth factorα(TGFα) and EGF receptor (EGFR) in the occurrence and development of hepatocellular carcinoma (HCC). METHODS: Reverse transcriptionpolymerase chain reaction (RTPCR) was employed. RESULTS: The positivity rate of EGF in HCC, pericancerous and normal liver tissues was 95.0%, 91.7% and 37.5%, respectively, and the positivity rate of TGFα was 85.0%, 83.3% and 25.0%, respectively, whereas the positivity rate of EGFR was 95.0%, 100% and 50.0% respectively. EGF and EGFR had a higher expression level in HCC than TGFα. CONCLUSION: The autocrine system of EGF/EGFR and /or TGFα/EGFR exists in HCC, but the EGF/EGFR system may play a more important role in the proliferation and differentiation of HCC.

    【Keywords】 hepatocellular carcinoma; epidermal growth factor; transforming growth factorα; epidermal growth factor receptor; reverse transcriptionpolymerase chain reaction ......

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