【摘要】 目的 了解出生缺陷围产儿的发生率、发生系统及缺陷分布情况，为临床预防和治疗提供依据。方法 回顾性分析1997～2004年我院产科分娩的7720例围产儿资料，对其中119例出生缺陷围产儿逐一进行分类和统计学分析。结果 8年间出生缺陷平均发生率为15.41‰，2001～2004年间发生率为21.65‰，1997～2000年间发生率为10.65‰，两个时期比较，差异有显著性(P<0.05)。前3位出生缺陷依次为心血管系统缺陷、多器官畸形、四肢缺陷。缺陷儿中孕妇有各种合并症者52例，占43.70%，存在可能致畸因素者75例，占63.03%。结论 孕早期是预防出生缺陷的关键，加强对高危妊娠的监测和产前诊断则是预防的重要手段，先天性心脏病的发生呈上升趋势，目前已位居我院出生缺陷的首位，应加强对其诊断及预防措施的研究。

    【关键词】 出生缺陷；围产儿

    Clinical study of 119 cases of birth-defects perinates

    JIANG Ying,WANG Gui-qin.

    Department of Obstetrics and Gynecology,Beijing Chaoyang Hospital Affiliated to the Capital University of Medical Sciences,Beijing 100020,China

    【Abstract】 Objective To learn the birth defect rate and the system and distribution of congenital defection in perinates and provide basis for prevention and treatment of birth defects.Methods We reviewed 7720 perinatal cases that were born between 1997 and 2004 in Department of Obstetrics of Beijing Chaoyang Hospital and made statistical analysis on 119 cases of birth defects perinates.Results The incidence of birth defects was 15.41‰ ......