卵巢肿瘤_____卵巢肿瘤；LY294002；紫杉酶

磷脂酰肌醇3激酶抑制剂LY294002联合紫杉醇对卵巢癌裸鼠移植瘤的治疗作用

http://www.100md.com 《第四军医大学学报》 2004年第12期

卵巢肿瘤,,卵巢肿瘤；LY294002；紫杉酶,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Effects of combined therapy of Phosphatidylinositol 3Kinase and Paclitaxel in ovarian cancer model in vivo

    WANG XiaoNan, XIN XiaoYan, HUA Wei

    Department of Obstetrics & Gynecology, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To evaluate the effects of combined therapy of Phosphatidylinositol 3Kinase (LY294002) and Paclitaxel in athymic mice xenogeneic transplant model of ovarian cancer. METHODS: Forty athymic mice were randomly divided into 4 groups (control, positive, Paclitaxel alone, and Paclitaxel plus LY294002), and were treated respectively. Athymic mice xenogeneic transplant model was established by inoculation (sc) with HO8910PM ovarian cancer cells. Body mass (BM) and diameter of tumor mass were measured, the peripheral blood was analyzed with autoanalysis meter, and MDA and SOD of liver were determined with fluorometry. RESULTS: Paclitaxel plus LY294002 increased the amounts of WBC and HGB in the peripheral blood(P<0.05)and inhibited the MDA level of liver(P<0.05). CONCLUSION: LY294002 can enhance the effects of Paclitaxel in the treatment of ovarian cancer. ......

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