Patientª²controlled analgesia combined with lornoxicam and epidural morphine for postoperative analgesia in patients undergoing gynecological surgery

    HE Daª²Yin, XIONG Liª²Ze, CHEN Shaoª²Yang, XIONG Dongª²Fang, LEI Yi

    Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi¡¯an 710033, China

    ¡¾Abstract¡¿ AIM: To study the analgesic and side effects of combining patientª²controlled analgesia (PCA) with lornoxicam and epidural morphine for postoperative analgesia. METHODS: 110 patients undergoing elective hysterectomy were randomly divided into 5 groups (n=22 each): Group C received epidural normal saline 5 mL, group F received postoperative PCIA with fentanyl, group L received PCIA with lornoxicam, group M received epidural morphine 2 mg and group ML received epidural morphine 1 mg combined with PCIA with lornoxicam. The efficacy of analgesia was assessed by Visual Analogue Scale (VAS) at 8, 24 and 48 h after surgery respectively. RESULTS: The VAS of groups F, L and ML was significantly less than that of group C at all time points after surgery (P<0.01) and the VAS of group ML was less than that of group F (P<0.01). The VAS of groups ML and M was less than that of groups L and C respectively at 8; 16; 24 and 36 h after surgery (P<0.05). The total dose of lornoxicam was (27.6¡À4.4) mg in group L and (19.2¡À3.6) mg in group ML respectively. There were significant differences between groups L and ML (P<0.01). Lornoxicam caused fewer side effects than fentanyl did (13.6% vs 31.8%). CONCLUSION: For postoperative pain relief, PCIA with lornoxicam combined with epidural morphine improves the analgesic effects and reduces the side effects in patients undergoing gynecological surgery. ......