短节段Barrett食管与贲门肠上皮化生的内镜与病理探讨
贲门肠上皮化生,,内窥镜术;Barrett,食管;贲门肠上皮化生;胃食管连接处,0引言,1对象和方法,2结果,3讨论,【参考文献】
Endoscopic and histological study on shortsegment Barrett’s esophagus and cardia intestinal metaplasiaCHANG Ying, GONG Jun, LIU Bin, ZHANG Jun, DAI Fei, WAN XiaoLong, WANG Tao
1Department of Gastroenterology, Second Hospital, Xi’an Jiaotong University, Xi’an 710004, China, 2Department of Emergence Surgery, Shaanxi Provincial People’s Hospital, Xi’an 710068, China
【Abstract】 AIM: To investigate the endoscopic and histological characteristics of shortsegment Barrett’s esophagus (SSBE) and cardia intestinal metaplasia ( CIM) and their associations with Helicobacter pylori gastritis and gastroesophageal reflux disease (GERD). METHODS: Eight biopsy specimens taken from lower esophagus, cardia and gastric antrum in 32 cases of SSBE and 41 cases of CIM were stained with haematoxylin/eosin (HE), alcian blue/periodic acidSchiff (ABPAS), alcian blue/high iron diamine (ABHID) and Gimenez, respectively. RESULTS: It was found that the SSBE patients were younger than the CIM patients (P<0.01). The incidence of dysplasia and incomplete intestinal metaplasia in SSBE patients was higher than that in the CIM patients(P<0.01, P<0.01). Compared with the CIM patients, the incidence of reflux symptomatic, endoscopic, or histological markers of GERD was higher in SSBE patients (P<0.01), whereas the incidence of H.pylori infection and antral intestinal metaplasia was lower in SSBE patients (P<0.05, P<0.01). CONCLUSION: The dysplasia risk is significantly higher in SSBE patients than in CIM patients, indicating two potentially different clinical processes of the two diseases. CIM is a manifestation of H. pylori infection associated with gastritis and multifocal atrophic gastritis, while SSBE may result from GERD. ......
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