子宫内膜异位症__(期刊论文)

原位杂交检测Epo, VEGF基因在子宫内膜异位症组织中的表达

http://www.100md.com 《第四军医大学学报》 2004年第6期

子宫内膜异位症,,红细胞生成素；内皮，血管；内皮生长因子；子宫内膜异位症；RNA，信使；原位杂交,原位杂交检测Epo,VEGF基因在子宫内膜异位症组织中的表达,0引言,1材料和方法,2结果,3讨

     Detection of Epo and VEGF mRNA in endometriotic tissues using hybridization in situ

    CAI GuoQing, CHEN BiLiang, FAN Yang, MA XiangDong, WANG DeTang, GUO HuiLing

    Department of Obstetrics & Gynecology , Xijing Hospital， Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To investigate the expression of mRNA of erythropoietin (Epo) and vascular endothelial growth factor (VEGF)in endometriotic tissues and its correlation with clinical biological behaviors. METHODS: Endometrium specimens were obtained from 38 endometriotic uteri and 35 normal uteri. The expression of mRNAs of Epo and VEGF in these paraffin embedded specimens was examined by in situ hybridization technique with specific cDNA probes. RESULTS: The expression of mRNA of Epo and VEGF in endometriosis was 3.08±0.48 and 2.95±0.43, respectively, which was significantly higher than those in normal endometrium (P<0.001). The expression of Epo mRNA was closely correlated with that of VEGF mRNA (C=0.733, P<0.001) and the expression of mRNA of Epo was closely correlated with the endometriosis' staging of American Fertility Society (P<0.01). CONCLUSION: The increased expression of mRNA of Epo and VEGF may play some important roles in the pathogenesis of endometiosis. ......

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