喹唑啉_____EGFR抑制剂；

合成五种喹唑啉类EGFRTK抑制剂的新方法

http://www.100md.com 《第四军医大学学报》 2004年第7期

喹唑啉,,EGFR抑制剂；,喹唑啉；,SOCl2回流法；,化学合成,0引言,1材料和方法,2结果,3讨论,【参考文献】

     five quinazolines as EGFR inhibitors

    CHEN Hui, JIANG Ru, SUN XiaoLi

    Department of Chemistry, School of Basic Medicine, Fourth Military Medical University, Xi’an 710033, China

    【Abstract】 AIM: To synthesize 4substituted aninine6,7dimethoxyl quinazoline, an effective epidermal growth factor receptor tyrosine kinase (EGFRTK) inhibitor. METHODS： A simple and timesaving SOCl2refluxed method was adopted to synthesize five quinazoline compounds as EGFR inhibitors. The five quinazoline compounds were prepared by using 2amino4,5dimethoxy benzoic acid as original material, which underwent ringclosing, halogenation and substitution. RESULTS： Intermediates and the five quinazolines were characterized by 1HNMR and were found to be in agreement with the corresponding molecular structures. CONCLUSION： This synthetic process is simple, convenient and cost saving.

    【Keywords】 EGFR inhibitors； Quinazoline； SOCl2 reflux method； chemical synthesis

    【摘要】目的：表皮生长因子受体酪氨酸激酶(EGFRTK)是肿瘤治疗的一个新靶点 ......

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