；β氨基酸__(期刊论文)

改进的“一锅煮”法合成3氨基3芳基丙酸

http://www.100md.com 《第四军医大学学报》 2004年第8期

；β氨基酸,,一锅煮法；β氨基酸；3氨基3芳基丙酸,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Improved onepot synthesis of 3amino3arylpropionic acids

    JIANG Ru, CHEN Hui, CHENG SiKun, JIN Ying, WANG QiaoFeng, SUN XiaoLi

    Department of Chemistry, School of Basic Medicine, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To improve the synthetic method of 3Amino3arylpropionic acid and obtain high yield. METHODS: Aromatic aldehyde and 3 equivalents of ammonium acetate were refluxed in methanol for 10 min to form Shiff base. Malonic acid was added and reaction mixture refluxed intensely for 16 h. The product was obtained and then characterized by NMR spectrum. RESULTS: Ten 3Amino3arylpropionic acids were prepared, of which 5 kinds wee new. The yields were 25%~79%, which were respectively higher than the values reported by literature. CONCLUSION: Our improved method, simple and easy, reduces the cost, and is of high value for industrial appliation.

    【Keywords】 onepot synthesis; βamino acid; 3amino3arylpropionic acid

    【摘要】目的：改进3氨基3芳基丙酸的合成方法 ......

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