Effects of hyperoxic solutions on blood pressure and blood gas during severe hemorrhagic shock in rabbits

    HU Bo, XIONG Liª²Ze, CHEN Shaoª²Yang, LEI Yi, WANG Qiang, ZHANG Hui

    1Department of Anesthesiology, Xijing Hospital, 2Department of Anesthesiology, College of Stamotology, Fourth Military Medical University, Xi¡¯an 710033, China

    ¡¾Abstract¡¿ AIM: To investigate the effects of hyperoxic solutions on blood pressure, blood gas and survival rate during severe hemorrhagic shock in rabbits. METHODS: Fortyª²eight rabbits weighing (2.2-2.8) kg were randomly divided into two groups (n=24 each): hyperoxic solutions group (HO group) and control group. Each group was randomly allocated to four experimental groups: hydroxyethylstarch (HES, n=6), polygenine (Pol, n=6), gelofusine (Gel, n=6) and Ringer¡¯s solution (RS, n=6). Anesthesia was induced with 30 mg/mL pentobarbital sodium 30 mg/kg. The right femoral artery was cannulated for MAP monitoring and blood collection, 45%-50% of the whole blood volume was exsanguinated in 5 min and MAP was rapidly reduced to 2.67 kPa. Thirty min later, the animals were resuscitated with various solutions based on group assignment within 10 min. Blood gas was analyzed before and 30 min after shock, at the end of resuscitation and 30 min and 60 min after resuscitation. The animals were carefully observed for 3 days and the survival rate at 24 h, 48 h, 72 h and 96 h was analyzed. RESULTS: There was no significant difference in PaO2 between HO group and control group after resuscitation. But, the survival rate of HO group was significantly higher than that of control group. In HO group, acidosis was reduced and increased and MAP was sustained MAP significantly. CONCLUSION: HO is more effective in the early therapeutic stage of hemorrhagic shock. ......