2型糖尿病__(期刊论文)

对氧磷酯酶 2 S311C基因多态性与2型糖尿病的关系

http://www.100md.com 《第四军医大学学报》 2004年第12期

2型糖尿病,,2型糖尿病；对氧磷酯酶2；TDIFP技术；单核苷酸多态性；基因,对氧磷酯酶2S311C基因多态性与2型糖尿病的关系,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Relationship between paraoxonase 2 S311C gene polymorphism and type 2 diabetes mellitus

    JIAO Kai, JIANG Hua

    Department of Endocrinology, Tangdu Hospital, Fourth Military Medical University, Xian 710038, China

    【Abstract】 AIM: To investigate the association of paraoxonase 2 (PON2) Ser311Cys (S311C) gene polymorphism with type 2 diabetes mellitus (T2DM).METHODS: The S311C polymorphism in the PON2 gene was genotyped by Templatedirected Dyeterminator Incorporation with Fluorescence Polarization (TDIFP) in 17 patients with type 2 diabetes mellitus and 16 normal controls.RESULTS: In the 17 patients, there were 5 carriers of PON2 SS genotype, 6 of CS genotype, 6 of CC genotype; while in the 16 controls, there were 11 carriers of PON2 SS genotype, 3 of CS genotype, 2 of CC genotype. Patients with T2DM had a higher frequency of PON2 C311 allele than normal controls (P<0.01). C311 allele appeared to have an association with T2DM. The odds ratio was 4.018 with a 95% confidence interval of 1.371-11.774. CONCLUSION: TDIFP can detect PON2 S311C gene polymorphism correctly and sensitively. PON2 C311 allele may be a susceptible gene of T2DM. ......

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