蛋白质类__(期刊论文)

荷瘤大鼠60Co局部照射后骨髓蛋白质的差异表达

http://www.100md.com 《第四军医大学学报》 2004年第14期

蛋白质类,,照射；大鼠；骨髓；电泳，凝胶，双向；蛋白质类,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Differential expression of bone marrow proteins in tumorbearing rats after 60Co local irradiation

    LI Bo, HAI ChunXu, QIN XuJun, HE Wei, LIANG Xin, LI WenLi, ZHANG XiaoDi, ZHAO KangTao, CHEN HongLi, LIU Rui

    Department of Toxicology, School of Preventive Medicine, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To study the differential expression of bone marrow proteins (BMPr) after 60Co local irradiation in tumorbearing rats. METHODS: Entitative tumor pieces were embedded into rat hind leg muscle to prepare tumor bearing rat model. After 60Co local irradiation, the bone marrows of rats in both tumor bearing and irradiated groups were removed to extract BMPr, respectively. Twodimensional polyacrylamide gel electrophoresis was used to analyze the differential expression of BMPr. RESULTS: Alterations were found in 24 proteins in tumor bearing rats after 60Co local irradiation, of which 2 novel proteins, 4 downregulated proteins, 1 upregulated protein and 17 proteins that disappeared following irradiation. CONCLUSION: The differential expression of BMPr can be induced by 60Co local irradiation in tumor bearing rats. ......

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